解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9460-5
更新日期:2014-08-01 00:00:00
abstract::Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9451-y
更新日期:2014-07-01 00:00:00
abstract::Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation,and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk betwee...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9427-y
更新日期:2014-07-01 00:00:00
abstract::Alzheimer's disease (AD) is associated with increased brain levels of β-amyloid (Aβ) peptides, which readily self-aggregate into fibrils and oligomers that have particularly deleterious properties toward synapses of excitatory glutamatergic neurons. Here, we examined the neuroprotective effects of 1-methyl-1,2,3,4,-te...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9440-1
更新日期:2014-05-01 00:00:00
abstract::Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9421-4
更新日期:2014-02-01 00:00:00
abstract::Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. A sublethal preconditioning has been proposed as a neuroprotective strategy against several central nervous system neurodegenerative diseases. We have recently demonstrated that autophagy is a pr...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9390-7
更新日期:2013-11-01 00:00:00
abstract::The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9403-6
更新日期:2013-10-01 00:00:00
abstract::Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9369-9
更新日期:2013-08-01 00:00:00
abstract::Organophosphate (OP) poisoning is associated with long-lasting neurological damage, which is attributed mainly to the excessive levels of glutamate caused by the intoxication. Glutamate toxicity, however, is not specific to OP poisoning, and is linked to propagation of damage in both acute and chronic neurodegenerativ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-013-9388-1
更新日期:2013-08-01 00:00:00
abstract::The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9372-1
更新日期:2013-07-01 00:00:00
abstract::Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease (PD). Our previous studies have observed that Rg1, a major pharmacologically active ingredient from Ginseng, could protect dopaminergic neurons by reducing nigral iron levels through regulating the expression of iron transporters...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9362-3
更新日期:2013-07-01 00:00:00
abstract::Microglial activation and subsequent release of toxic pro-inflammatory factors are believed to play an important role in neuronal cell death associated with Parkinson's disease (PD). Compounds that inhibit microglia activation and suppress pro-inflammatory factor release have been reported to have neuroprotective effe...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9328-5
更新日期:2013-02-01 00:00:00
abstract::Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9346-3
更新日期:2013-02-01 00:00:00
abstract::Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9321-z
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induct...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9333-8
更新日期:2013-01-01 00:00:00
abstract::Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9312-0
更新日期:2012-11-01 00:00:00
abstract::It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9316-9
更新日期:2012-08-01 00:00:00
abstract::The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, inc...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9301-8
更新日期:2012-08-01 00:00:00
abstract::Effects of chemotherapeutics on glioma cell lines and spheroids are usually investigated without evaluating the effects of chemotherapeutics on normal brain tissue. To perform such investigations, the aim of this study was to establish a panel of markers for detection of general cell death and more specific neuronal a...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9300-9
更新日期:2012-07-01 00:00:00
abstract::Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9290-7
更新日期:2012-05-01 00:00:00
abstract::Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9294-3
更新日期:2012-05-01 00:00:00
abstract::Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increas...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9251-1
更新日期:2012-02-01 00:00:00
abstract::Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9250-2
更新日期:2011-11-01 00:00:00
abstract::The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9244-0
更新日期:2011-11-01 00:00:00
abstract::This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9235-6
更新日期:2011-08-01 00:00:00
abstract::1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9228-5
更新日期:2011-08-01 00:00:00
abstract::Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9180-4
更新日期:2011-04-01 00:00:00
abstract::Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9165-3
更新日期:2011-02-01 00:00:00
abstract::Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9153-7
更新日期:2011-01-01 00:00:00
abstract::Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-010-9163-5
更新日期:2010-11-01 00:00:00
abstract::Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9125-y
更新日期:2010-05-01 00:00:00
abstract::Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated the role of Zn in the regulation of these two critical events. A low Zn availability leads to decreased cell viability in hum...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9067-4
更新日期:2010-01-01 00:00:00
abstract::Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...
journal_title:Neurotoxicity research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s12640-009-9092-3
更新日期:2009-11-01 00:00:00
abstract::Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9081-6
更新日期:2009-11-01 00:00:00
abstract::Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9054-9
更新日期:2009-10-01 00:00:00
abstract::Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9063-8
更新日期:2009-08-01 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9049-6
更新日期:2009-07-01 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9043-z
更新日期:2009-05-01 00:00:00
abstract::Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9028-y
更新日期:2009-04-01 00:00:00
abstract::High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9018-0
更新日期:2009-02-01 00:00:00